(From left to right): Chang Lu, Travis Murphy, Richard Yu, Yan Zhu, Zhenning Cao, Nelie Loufakis, Chen Sun, Yining Hao, Sai Ma (July 2014).
Our research is concerned with the new science and technology generated by applying
micro/nanofabricated structures and devices to biological studies and biosensors.
One emphasis in our research is to develop high-throughput microfluidic tools to manipulate and analyze single cells and extract
biological information. We have developed/invented microfluidic chemical cytometry, Coherent anti-stokes Raman scattering (CARS) flow cytometry,
electroporative flow cytometry, total internal reflection fluorescence (TIRF) flow cytometry over recent years for a variety of applications.
Another thrust in the group is on developing flow-through electroporation for efficient gene delivery into cells. Our ultimate goal is to apply this technique to
create genetically modified cells for cancer immunotherapy, stem cell therapy and tissue regeneration. Our recent efforts have been focused on developing sensitive assays for studying epigenetics at the genome level. Our tools will facilitate strategies for epigenomic examination of patient samples, in the context of precision medicine.
- Aug 2015, Lu (contact PI) and Tan received a R21 grant (423K for 2 years) from NIH/NHGRI.
- Oct 2014, Scott Verbridge (PI) and Lu received a R21 grant (406K for 2 years) from NIH/NIBIB.
- April 2014, Dr. Tan and Lu (MPI) received a R21 grant (422K for 2 years) from NIH/NIBIB.
- March 2014, Dr. Lu (PI) received a R01 grant (1.3 M for 4 years) from NIH/NIBIB. The team includes collaborators Dr. Liwu Li and Dr. Kai Tan (University of Iowa).
- April 2013, Dr. Lu (PI) received a R21 grant (710K for 3 years) from NIH/NCI IMAT program. This will be a collaboration with Dr. Al Baldwin (UNC).