Chang Lu, Associate Professor
Department of Chemical Engineering,
Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences
Virginia Tech
Blacksburg, VA 24061


Microfluidics, Single Cell Manipulation, Epigenomics and Genomics, and Cellular Analysis


Lu Group 2011  
(From left to right): Chang Lu, Travis Murphy, Richard Yu, Yan Zhu, Zhenning Cao, Nelie Loufakis, Chen Sun, Yining Hao, Sai Ma (July 2014).  

Our research is concerned with the new science and technology generated by applying micro/nanofabricated structures and devices to biological studies and biosensors. One emphasis in our research is to develop high-throughput microfluidic tools to manipulate and analyze single cells and extract biological information. We have developed/invented microfluidic chemical cytometry, Coherent anti-stokes Raman scattering (CARS) flow cytometry, electroporative flow cytometry, total internal reflection fluorescence (TIRF) flow cytometry over recent years for a variety of applications. Another thrust in the group is on developing flow-through electroporation for efficient gene delivery into cells. Our ultimate goal is to apply this technique to create genetically modified cells for cancer immunotherapy, stem cell therapy and tissue regeneration. We also work on conducting cellular assays based on genetic/epigenetic and proteomic analysis. Finally, we are interested in developing various biosensors for different applications.


NEW (May 2014):Recruiting postdocs and graduate students, interested individuals should contact Dr. Chang Lu by email.

  • Oct 2014, Scott Verbridge (PI) and Lu received a R21 grant (406K for 2 years) from NIH/NIBIB.

  • April 2014, Dr. Tan and Lu (MPI) received a R21 grant (422K for 2 years) from NIH/NIBIB.

  • March 2014, Dr. Lu (PI) received a R01 grant (1.3 M for 4 years) from NIH/NIBIB. The team includes collaborators Dr. Liwu Li and Dr. Kai Tan (University of Iowa).

  • April 2013, Dr. Lu (PI) received a R21 grant (710K for 3 years) from NIH/NCI IMAT program. This will be a collaboration with Dr. Al Baldwin (UNC).